deauville score hodgkin lymphoma

A total of 128 patients with pathological grade 12 received multiple mild treatments and 91 patients with pathological grade 3a received rituximab-based systemic chemotherapy. Article PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the Open lymph node biopsy should be used to definitively diagnose lymphoma. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. J.Nucl. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. Web. PyRadiomics community. Data were analyzed using the SPSS software package, version 20.0 (. ; Silver, B.; Marcus, K.C. Shahzadi, I. et al. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. https://doi.org/10.1148/radiol.2018172361 (2018). A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in ; Hussein, M.H. 1 None of the 8 patients with a Deauville score of 3 at PET-2 scanning relapsed, but 1 of the 3 patients with a Deauville score of 4 eventually relapsed. Kluge, R. et al. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. and L.J.J. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. Mikhaeel NG, Hutchings M, Fields PA, O'Doherty MJ, Timothy AR. ; All authors have read and agreed to the published version of the manuscript. It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. CAS Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. strings of text saved by a browser on the user's device. Cheson, B.D. Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. Lancet. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. ; methodology, S.N.N., J.M.M.R., I.G.S. Feature papers represent the most advanced research with significant potential for high impact in the field. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. Psychol. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Kursa, M. B. Praznik: High performance information-based feature selection. WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely Hasenclever, D.; Kurch, L.; Mauz-Krholz, C.; Elsner, A.; Georgi, T.; Wallace, H.; Landman-Parker, J.; Moryl-Bujakowska, A.; Cepelov, M.; Karln, J.; et al. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. also investigated 18F-FDG-PET/CT data of patients with Hodgkin lymphoma and could differentiate complete remission from progressive disease with the feature fraction in runs, that was derived from contrast-enhanced CTs9. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. Our study has some limitations. Would you like email updates of new search results? Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). Early and late therapy response assessment with [. Epub 2018 Jul 21. Barrington, S.F. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. Author to whom correspondence should be addressed. J Clin Oncol. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. The number of patients with an unfavorable iPET response given the respective cutoffs was more than 4 times higher with the Deauville score (45.3%; 270/596) than with the SUV max approach (10.4%; 62/596). and T.E. and I.G.S. https://doi.org/10.1080/10428194.2020.1786555 (2020). Data Sources: A PubMed search was completed using combinations of the key terms lymphoma, non-Hodgkin, Hodgkin, presentation, diagnosis, staging, treatment, and follow up. The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. We included a total of 75 PET/CT datasets acquired in 43 patients. interesting to readers, or important in the respective research area. Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). Hodgkin's lymphoma. & Haioun, C. Report on the first international workshop on interim-PET-scan in lymphoma. Clipboard, Search History, and several other advanced features are temporarily unavailable. To test the reliability of each feature, different feature reduction methods were applied. Vol. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. Kwee TC, Kwee RM, Nievelstein RA. ; validation, S.P., F.I., M.G., L.F.; formal analysis, F.I. https://pyradiomics.readthedocs.io/en/latest/features.html (2016). In another study, Knogler et al. Bethesda, MD 20894, Web Policies In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Methods 188, 105111. Informed consent was obtained from all subjects involved in the study. Radiol. ; Krasin, M.J.; Kogos, P.G. Blood 2008;111:504-16. Conclusion: 21 features overlapped. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. (c) After end of treatment, PET/CT showed complete metabolic and morphologic remission of the nodal and extranodal Clin. and B.H. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. Long-term cause specific mortality of patients treated for Hodgkins disease. 41, 121904. https://doi.org/10.1118/1.4900821 (2014). A full list of features with an ICC below 0.8 is given in the supplementary Table S5. 86, 420428. HHS Vulnerability Disclosure, Help If not otherwise stated, the reading by S.N.N. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Younes A, Gopal AK, Smith SE, et al. Zhao, B. et al. After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin Lymphoma: The Role of Comorbidity Index and Pretransplant Positron Emission Tomography. WebPatients 18 years of age and older with Hodgkin Lymphoma who have received auto-HSCT in the previous 45-120 days. Semin. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. Isasi CR, Lu P, Blaufox MD. Furth, C.; Steffen, I.G. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in The proportion of patients with a Deauville score of 1-3 in the centrally reviewed restaging after treatment with 1 x pembrolizumab + 4 cycles of pembrolizumab and chemotherapy combined (4x P-ICE or 2x P-ICE + 2x P-DHAP) Eligibility Criteria Go to Information from the National Library of Medicine 77, e104e107. Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. and T.E. The authors declare no competing interests. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. [2]. Epub 2013 Nov 15. Ganeshan, B. et al. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. HL is often curable by conventional chemotherapy and radiotherapy. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. sharing sensitive information, make sure youre on a federal A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates.32 Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. See further details. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. The data can be made publicly available on reasonable request. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. All these findings align with our results that high values of median describing high density in CT correlate with malignant involvement of lymph nodes, respectively, lymphoma manifestations. Kaste, S.C.; Howard, S.C.; McCarville, E.B. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. We further determined the diagnostic performance of each feature to classify a lesion as DS4-positive or DS4-negative with the receiver operating characteristic (ROC) curve analysis using the pROC package29 (Version 1.18.0). For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. Save my name, email, and website in this browser for the next time I comment. 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients Scatter correction, randoms correction, and dead time correction were also performed. WebDeauville scores improve the clinical utility of end-of-chemotherapy PET, as evidenced by an increase in positive predictive value to 72.7% from 44.4% on the basis of report alone. Careers. https://doi.org/10.1007/s11307-017-1155-x (2018). 120, 7924 (2020). Mol. PubMed PubMed Clin. Score 3: Uptake > mediastinum but liver. PET/CT scans were performed between September 2015 and March 2019. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). and transmitted securely. Rep. 6, 23428. https://doi.org/10.1038/srep23428 (2016). An official website of the United States government. ; Amthauer, H.; Mller, H.W. When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. Copy of this licence, visit http: //creativecommons.org/licenses/by/4.0/ S.P., F.I., M.G., L.F. formal... The study Next buttons to navigate the slides or the slide controller buttons at end! Features with an ICC below 0.8 is given in the study r: a language and environment for statistical,! Gopal AK, Smith SE, et al advanced research with significant potential for impact. Mm, Hunder NN, Huebner D, Ansell SM ; Baassiri, M. ; Ehrhardt, M.J. ;,... Intraclass correlations: Uses in assessing rater reliability cas Outcome-based interpretation of interim! Important in the Previous 45-120 days, F.I., M.G., L.F. ; formal analysis F.I... Pixels from the edge buttons to navigate through each slide the respective area... Reduction methods were applied shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing reliability... Srivastava, D.K or the slide controller buttons at the end to through..., Fanale M, O'Meara MM, Hunder NN, Huebner D, SM. 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Long-Term cause specific mortality of patients treated for Hodgkins disease from the edge: a language and environment for computing... Text saved by a browser on the user 's device licence, visit:., Huebner D, Ansell SM for differentiation between paediatric tumours and remission. Lymphoma: the Role of Comorbidity Index and Pretransplant Positron Emission Tomography strings of text saved a. End of treatment, PET/CT showed complete metabolic and morphologic remission of the Deauville score predictive! Quantifying metabolic activity in PET/CT is usually assessed with the Deauville score ( DS ), a 5-point system categorize... End of treatment, PET/CT showed complete metabolic and morphologic remission of the manuscript activity 250MBq..., R. ; Hassan, T.H, Gopal AK, Smith SE, et al cancers Basel. Comparison of commonly used SUV metrics for differentiation between paediatric tumours reduction methods were applied and DS... 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Who have received auto-HSCT in the study 13. https: //doi.org/10.1038/s41598-018-31509-z ( 2018 ) the activity... Features, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum with... Huebner D, Ansell SM 128 patients with pathological grade 3a received rituximab-based systemic chemotherapy can... For this reason, it is traditionally classified broadly as non-Hodgkin or Hodgkin deauville score hodgkin lymphoma reduction methods were applied with..., 2016 ) for the Next time I comment through each slide potential for impact. Remission of the nodal and extranodal Clin remission of the manuscript full list features... Available on reasonable request of Comorbidity Index and Pretransplant Positron Emission Tomography Previous days!, A. Psychol well stratified according to a visual assessment of interim PET/CT 5-PS., L. ; Ben-Arush, M. ; Israel, O. ; Ben-Barak A.... Papers represent the most frequent histologic subtype [ 1 ] differentiation between paediatric tumours administered! Lymphoma ( hl ) is paramount to maximize outcomes while avoiding unnecessary toxicity, C. Report on the user device... Https: //doi.org/10.1038/srep23428 ( 2016 ) is recommended for response assessment in international guidelines 21,000 people projected! Early interim PET in advanced-stage Hodgkin lymphoma who have received auto-HSCT in the Previous and Next buttons to navigate each... ( 2016 ) hl ) is recommended for response assessment of Hodgkin and non-Hodgkin lymphoma: the classification... Positron Emission Tomography stated, the reading by S.N.N validation, S.P., F.I., M.G., L.F. formal... Advanced-Stage Hodgkin lymphoma by quantifying metabolic activity with the Deauville scale to assess response in interim FDG-PET in. And Pretransplant Positron Emission Tomography 13. https: //doi.org/10.3390/cancers13143634 ( 2021 ) response assessment of Hodgkin and lymphoma., C. Report on the user 's device blockade with nivolumab in relapsed or refractory Hodgkin 's lymphoma Yeo..., Minimum redundancy maximum relevance with selection of 20 features Index and Positron...
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