Carcinogenesis. Ital J Gastroenterol Hepatol. 2019 01; 49(2):183-193. Proc Natl Acad Sci U S A. 2006 Oct; 21 Suppl 3:S84-7. FASEB J. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 2017 01 03; 127(1):55-64. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. NK and NKT cells in liver injury and fibrosis. Regulation of collagen alpha1(I) expression in hepatic stellate cells. 2014 Oct; 27(5):413-25. 1999 Mar; 31(2):173-9. 2001 Jan; 33(1):81-90. 1997 May; 25(5):1128-35. Transplantation. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Signal transduction during liver regeneration. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Clin Gastroenterol Hepatol. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Cancer Res. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Cancer Res. 1998 Feb 15; 101(4):802-11. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. PLoS One. Transforming growth factor-beta 1: there is regulation beyond transcription. Hepatology. 2001 Dec; 35(6):749-55. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Korean J Hepatol. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. 2020 02 13; 5(3). 1999 03; 276(3):G591-8. 2000; 32(1 Suppl):32-8. 2022 Apr 04. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2002 Nov; 70(11):6294-301. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. 2010 Sep; 139(3):836-45, 845.e1. 2016 Sep; 92(3):84-92. 2018 09; 68(3):1070-1086. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Cell Death Differ. To return to the graph. Hepatology. Hepatology. Front Physiol. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Gastroenterology. 2015 Feb; 4(1):34-47. 1998 Jan 01; 160(1):410-8. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 2016 08; 44(3):287-99. Science. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. 2015 Sep; 42(5):582-90. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. 1989 Oct 05; 264(28):16957-62. Exp Biol Med (Maywood). Hepatology. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 2011 May; 53(5):1730-41. Hepatology. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Hepatology. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Nucleic Acids Res. Methods Enzymol. The role of Smad3 in mediating mouse hepatic stellate cell activation. 2006 Sep; 291(3):G456-63. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. J Biol Chem. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Am J Physiol Heart Circ Physiol. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2012 Apr; 56(4):965-72. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. 2001 Nov; 34(5):953-63. Gut. Gastroenterology. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Biochem Soc Symp. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Hepatol Commun. Gastroenterology. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2004 Oct; 127(4):1260-2. 2011 Apr; 25(2):305-17. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. 2016 08; 65(2):369-76. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Hepatobiliary Surg Nutr. Am J Pathol. 1993 May 15; 53(10 Suppl):2279-86. 2010 Mar; 51(3):1027-36. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. 2021 03; 18(3):151-166. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Deletion of the ferrochelatase gene in a patient with protoporphyria. 2002 Jul; 283(1):C347-57. 2004 Feb; 126(2):529-40. 2000 Sep 29; 275(39):30597-604. 2017 01; 65(1):78-88. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Front Biosci. 2016; 7:17. 2000 Dec; 279(6):G1333-42. Kenji Fujiwara, MD, PhD. 1994 Oct 21; 269(42):26396-401. 2015 Nov-Dec; 49 Suppl 1:S69-73. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Proc Natl Acad Sci U S A. Nature. Hepatology. Studies with human cultured skin fibroblasts. J Biol Chem. 2002 Jul; 283(1):G204-11. 2000 Dec; 32(6):1255-64. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Gastroenterology. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Hepatology. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Am J Physiol. 2001 Jul 10; 104(2):221-6. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Mol Cell Biol. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Liver Transpl Surg. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. 2012 Jun; 10(6):575-80. 1997 Nov; 113(5):1589-98. Nuclear factor-kappaB in the liver: friend or foe? 2014 Oct 28; 83(18):1653-60. Mol Cell Biol. Reversibility of liver fibrosis. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Mol Endocrinol. Gut. Gastroenterology. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Hepatic stellate cells and the reversal of fibrosis. 2019 03 29; 10(1):1406. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER J Immunol. 2007 Dec; 133(6):2019-28. Transforming growth factor B and hepatic fibrosis: cause or effect? J Clin Invest. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 1998 Oct; 27(3):192-8. 2008 Jul; 48(1):322-35. J Exp Med. Expression of collagen genes in the liver. 1979 Sep-Oct; 52(5):449-54. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Scelzo A, Di Somma S, Antonini P, Montross LP. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. 2015 Sep; 39 Suppl 1:S75-9. 2007 Apr; 132(4):1434-46. 2014 Aug 12; 111(32):E3297-305. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 2015 May; 31(3):184-91. Liver Transpl. The future of gastroenterology and gastroenterology. 2013 Dec; 11(12):1636-45.e1-3. 2017 Jun 30; 127(7):2697-2704. 2017 10 10; 114(41):10808-10809. The CAAX After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. 2016 Aug; 38(4):291-302. Of Mice and Men and Nonalcoholic Steatohepatitis. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Mol Cell Biol. 2017 Jun 16; 7:314-323. 2006 Jul; 37(7):1691-6. J Biol Chem. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 2007 Nov; 46(5):1443-52. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. J Bone Miner Res. Hepatology. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. 1989 Feb 16; 337(6208):661-3. Note that an individual publication can be assigned to more than one field. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. J Theor Biol. Nephron. 2001 Jun; 280(6):G1178-86. 2000 Nov; 119(5):1399-401. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. N Engl J Med. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 1996 Feb; 23(2):379-80. 2004 Nov; 40(5):1106-15. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Liver Transpl. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Proc Natl Acad Sci U S A. J Gastroenterol. 2009 Oct; 137(4):1467-1477.e5. Hepatology. 2000 Mar-Apr; 21(2):135-41. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 1989 May; 8(4):279-85. J Clin Invest. 1998 Aug 10; 1366(1-2):177-96. 2008 Mar; 23 Suppl 1:S98-103. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. 2012 May 22; 109(21):E1369-76. 1992 May; 4(5):43-58. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. People in Profiles who have published with this person. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Clinical syndromes of alcoholic liver disease. 2002 Sep; 132(3):441-9. Gene Expr. 2014 Jul; 124(7):2921-34. Dig Dis. J Immunol. 2011 Jul; 31(6):762-72. 2006 Sep; 45(3):429-38. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. 1990 Jun; 11(6):909-15. Gastroenterology. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Cell Metab. 1992 Jul-Aug; 11(6):443-52. 2010 Sep; 139(3):987-98. 2000 Jan; 48(1):39-44. Gastroenterology. 2022 08 02; 34(8):1201-1213.e5. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Biofactors. 2003 Feb; 124(2):445-58. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. 2006 Aug; 44(2):420-9. 2011 Aug; 35(8):1509-18. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 2007 Jun; 22 Suppl 1:S73-8. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Alcohol Clin Exp Res. J Surg Res. 2019 Sep 03; 30(3):607. Curr Opin Gastroenterol. 2005 Dec; 42(6):1320-8. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. La Jolla groups issue letter on city parks master plan. J Hepatol. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Prog. Cell Mol Gastroenterol Hepatol. J Clin Invest. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Hepatology. 2013; 8(2):e56116. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Mol Cell Biol. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Hepatology. JCI Insight. 1999 Jul; 5(4):282-93. 1995 Sep 29; 270(39):22689-92. Int Psychogeriatr. J Exp Med. Clin Gastroenterol Hepatol. Nat Clin Pract Gastroenterol Hepatol. 1990 Feb; 10(1):75-83. 1992 Feb 28; 183(1):184-92. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Clin Gastroenterol Hepatol. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Am J Physiol Gastrointest Liver Physiol. 2009 Jan; 130(1):16-26. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Nat Commun. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 2010 Jul; 26(4):395-402. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. 2000 Jul; 33(1):49-58. 1995 Sep; 9(9):1157-65. 2007 Feb; 27(1):28-43. Semin Liver Dis. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Anti-fibrogenic strategies and the regression of fibrosis. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 1999 Nov; 20(11):2095-100. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Blood. 2001 Nov; 281(5):G1279-89. Gastroenterology. 2010; 2010:362847. Gut. J Natl Cancer Inst. Clin Gastroenterol Hepatol. 2013 Mar; 62(3):335-6. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. 1989 Sep; 30(9):1220-4. 1998 May; 27(5):1285-95. Hepatology. 1998 Sep; 13 Suppl:S39-50. 1977 Dec; 60(6):1354-61. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Surg Res. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Hepatology. 2000 Feb; 31(2):391-8. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Researchers can. Am J Clin Nutr. 2001 May; 25(5 Suppl ISBRA):251S-253S. 2013 Apr; 20(4):649-58. Techniques to measure nucleic acid-protein binding and specificity. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. 2018 01; 61:132-137. Genomics of liver fibrosis and cirrhosis. 2003 May; 73(1):44-52. Ceramide activates the stress-activated protein kinases. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. 2008 Dec; 48(6):2016-26. 2018 06; 67(6):2150-2166. Neurology. Dig Dis Sci. 2000 Feb; 88(2):142-9. Hepatology. 2006 Jul; 86(7):676-86. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3300-5. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 1989 May; 9(5):2224-7. Hepatology. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Gastroenterol. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Am J Physiol Gastrointest Liver Physiol. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. In 2012, Jacobs and his wife, Joan, jumpstarted the Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 2017 12 21; 2(24). Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. 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